Nitric Oxide (NO) is the mediator of the numbing (analgesic) effect of opioids.It offers pain relief in a number of ways.The most encouraging findings was the diminishing of pain for those suffering from neuropathy. Scientific data shows the dual effect of NO on pain transmission and control, the molecular mechanisms involved in these effects and also the potential use of NO in pain.
NO was shown in the early 1990’s to be the mediator of the analgesic effect of opioids such as morphine (SH Ferreira, 1991). This research group also found that morphine initiates a release of NO whereupon pain relief ensued. They found that NO is involved in many physiological processes and the evidence indicates that NO plays a complex and supportive role in the modulation of pain.
Morphine binds to a nerve cell receptor and initiates a release of NO of which the consequence is the lessening of pain, mediated by cGMP, (the mechanism by which opioids work). Therefore, it was found that raising local levels of NO can lessen pain.
According to the findings of Thomas Burke, PhD, “NO reduces pain directly by increasing cGMP and indirectly by increasing circulation to restore normal membrane potential and reduce pressure on nerves due to localized edema.”In the process of assisting in decreasing pain it also assists in decreasing inflammation through the delivery of nutrients and oxygen throughout the body.
Neuropathy is a condition resulting in damage to nerves caused by diabetes, hereditary disorders, inflammatory infections, auto-immune diseases, chemo-induced neuropathy, poor nutrition, medications and alcoholism. Nerves can only survive if there is a flow of blood which offers energy in the form of oxygen and nutrients.
Most of the causes of neuropathy are due to the lack of adequate nutrients and oxygen and the decreased synthesis of ATP, affecting normal membrane potential. Nerves operate at -70 mV and signal pain at -20mV. When there is a lack of blood circulation the membrane potential resembles the -20mV level that would signal pain. Poor circulation is first perceived as pain. NO stimulated vasodilation increases nutrients and oxygen to nerves and resets the membrane potential, thereby re-establishing more normal levels of homeostasis and less pain.The problem with pain killers, which is what is prescribed to patients with neuropathy is that they do nothing to restore normal nerve function. NO not only has been shown to mitigate pain but to re-establish nerve function.
Cardio Miracle’s Nitric Oxide Supplement allows sufficient oxygen, nutrients and glucose to be transported to nerve cells, positively affecting ATP production and, in turn, potassium/sodium homeostasis essential for neurotransmission. All these beneficial reactions occur simply by triggering your body to produce nitric oxide (NO). Additionally, by improving neurotransmission it helps to reduce pain.
Cardio Miracle contains a complex of a bioavailable amino acid complex that triggers your body to produce its own NO. While it dilates the arteries, it strengthens and reduces inflammation via two channels. One channel is through the effect of specific ingredients known for their anti-inflammatory response in the body. Ingredients such as; turmeric, hawthorn berry, resveratrol, grape seed extract, astaxanthin, atralagus, green tea extract and ginseng.
The other channel is through its detoxifying properties. Cardio Miracle contains L-ornithine which is known to convert ammonia in the blood to urea. This is important because the accumulation of toxins in the blood leads to inflammation. So, by clearing the blood of toxic ammonia inflammation can be reduced.
Cardio Miracle Nitric Oxide supplement, boosts the body’s NO production to maximum levels for up to 12 hours.
All it takes is two drinks a day to better circulation and increased health.
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