Coenzyme Q10’s most absorbable form is known as Ubiquinol. C0Q10 is a potent enzyme that enhances heart health. Coenzyme Q10 is produced by the body but as by the time the body reaches 30 years of age its production begins to severely diminish. Coenzyme Q10 is a critical factor in maintaining the health of every cell in the body. It protects the heart muscle and tissue against free radical assault and absorbs oxidation within the arterial system. Two key markers for heart disease are Gamma Glutamyl Transferase (GGT) and C-reactive protein. Elevated levels increase the risk of heart disease. Ubiquinol downregulates C-reactive proteins and GGT, reducing the risk of heart disease.

Fiber has a symbiotic relationship with other nutrients that help support healthy cholesterol, cardiovascular health, and maintain a healthy digestive tract. Healthcare professionals are reporting that 75% of people have some form of dysbiosis, or poor gut health. Fiber, taken as a prebiotic, can help alleviate some of those challenges. Not only does Cardio Miracle provide healthy fibers through the organic powders, the product has additional soluble fiber which helps increase nutrient absorption and bulks up the stool which can add benefits for those who may be constipated.

Dietary fibers can act by changing the nature of the contents of the gastrointestinal tract. In particular prebiotic fibers have had a lot of attention recently because healthcare professionals are recognizing how important they are for balance within the human microbiome. Soluble and insoluble fibers encourage healthy flora in the gastrointestinal tract.

Cardio Miracle utilizes a very high quality grape seed extract with a high concentration of active polyphenols and with antioxidant properties. Grape seed extract helps to support nitric oxide synthase in the endothelium, supporting healthy blood pressure. Grape seed extract is a flavonoid that has a high affinity for collagen structures, including those of your arteries and heart. It is known to support the structural integrity of tissue, helping in some instances to minimize physical wear and tear in the body. Studies may suggest that it may also help strengthen vein health and skin structure.

Hawthorn berry is one of the most potent antioxidants known for healing several parts of the body. Its packed with beneficial flavonoids, saponins, phenolic acids, oligomeric proanthocyanidins (OPCs), quercitin, procyonid, malic acid, and citric acid and still other phytonutrients that act as potent antioxidants and stimulate internal healing mechanisms.

Hawthorn berry helps protect against the formation of plaque, which leads to a health problem known as atherosclerosis. One animal study found that extracts of the plant given to rabbits with high cholesterol helped reduce cholesterol levels, In another study involving mice, hawthorn berry reduced LDL levels.

The tincture of hawthorn berries also reduced the production of cholesterol in the liver of rats who were being fed a high-cholesterol diet. Studies to determine if hawthorn will confer the same effects in people are needed, but the results are promising.

Several studies have similar conclusions that hawthorn significantly improved heart function and patients' ability to exercise as well as shortness of breath fatigue.
Several studies have found that hawthorn may promote balanced blood pressure.[6]

Those who received the hawthorn preparation experienced improved blood flow to the heart and were also able to exercise for longer periods of time without suffering from chest pain.

Hawthorn berry tea can have dramatic effects too. Studies demonstrate hawthorn berry tea as an intestinal, reducing bloating and cramping. It boosted gut health, making the environment less tolerant of parasites, such as tapeworms, and other infections.

Ionic Trace Minerals help to support normal PH balance within the body which facilitates greater absorption of Nitric Oxide. Ionic minerals are easily and quickly absorbed and taken into the cells that line the intestinal tract.

These minerals may are often employed in the body’s many physiologic activities, including nutrient transport, enzyme reactions, metabolism help, and immune system support.

L-Citrulline is a precursor to arginine in the body. L-citrulline converts to arginine which then converts to Nitric Oxide (NO). It essentially acts like a time-released L-arginine extending the life of L-arginine so it can continue to trigger the production of nitric oxide.

Citrulline bypasses the liver and unlike arginine, is not subject to breakdown by arginase. After supplementation, L-citrulline is converted into arginine in the kidneys. Despite claims that L-citrulline alone is sufficient to raise NO levels this position was contradicted by a 2014 Japanese study that showed the combination of both L-arginine and L-citrulline raises plasma L-arginine levels, and causes a significantly greater increase in plasma nitric oxide.

This means L-citrulline supplementation improves the ammonia recycling process and nitric oxide metabolism. L-citrulline is also used to alleviate erectile dysfunction caused by high blood pressure.

L-arginine and L-ornithine lose absorption value when supplemented in doses of 10g or more, which can result in diarrhea. L-Citrulline does not have this side-effect, but rather increases plasma levels of all three amino acids.

L-citrulline is found in watermelon rinds (not as much in the red stuff). Cardio Miracle’s L-citrulline is sourced from watermelon rinds.

Ornithine is a non protein and one of the three amino acids involved in the urea cycle. Along with L-arginine and L-citrulline, Ornithine reduces elevated ammonia levels. The kidneys convert L-Ornithine into arginine, which helps to produce nitric oxide.

L-Ornithine binds with a molecule known carbamoyl phosphate and then converts to L-citrulline where it releases the urea as the end product.

L-Ornithine’s synergistic relationship with the anti-aging amino acid L-arginine increases strength and endurance according to a recent study. And according to a study in Nutrition Research, people who took ornithine were less fatigued from exercise than were people who took a placebo. The study found that ornithine helps the body use energy and combat fatigue more efficiently. Scientist believe ornithine supports proper liver function, prevents fatigue, and boosts performance during prolonged exercise.

L-Ornithine provides athletic support by helping flush out excess ammonia and nitrogen from muscles during exercise.

Some research even suggests that ornithine together with l-arginine may help increase levels of human growth hormone

One clinical trial found that when burn patients took 10-30 grams of ornithine alpha ketoglutarate, OKG, daily they experienced faster healing. In addition, cancer patients taking OKG experienced faster recoveries as well.

Cardio Miracle’s sugar-free formula is sweetened with Stevia and sugar alcohol (Erythritol).

The three highest sources of Procyanidins is Grape Seed Extract (GSE), Pine Bark and Pycnogenol. Each has its merits and work in tandem with arginine and is so included to further enhance Cardio Miracle. This creates synergistic benefits and super boosts the anti-inflammatory effect of our formula. Proanthocyanin bioflavonoids are virtually identical whether they come from pine bark, grape seeds, lemon tree bark, cranberries, or hazel nut tree leaves. The difference is in the varying concentration in the different plant. GSE has the highest concentration of Proanthocyanin’s, 95% concentration, and it was selected for use at impactful levels in Cardio Miracle. Pine bark extract protects against oxidative stress by increasing synthesis of antioxidative enzymes and by scavenging of free radicals.

Pycnogenol was shown to improve blood glucose control in clinical studies. It also supported increased blood flow when combined with nitric oxide boosting L-arginine. This cardioprotective effect is greatly enhanced when Pycnogenol and L-arginine AKG is combined and may also help with erectile dysfunction.

The combination of L-arginine and GSE may enhance muscle function and performance; and when combined with other synergistic antioxidants like Pine Bark, Vitamins C and E, and Resveratrol it becomes a powerhouse of benefits for repairing and maintaining cardiovascular health.

Recently, scientists discovered that pomegranate juice may enhance the bioactivity of nitric oxide synthase in endothelial cells. Furthermore, pomegranate’s antioxidant properties help to protect nitric oxide from oxidative destruction. Pomegranate juice has also been shown to support the positive expression of nitric oxide synthase in both healthy and unhealthy blood vessels.

According to a study published in a June 2010 issue of Science Daily, the nitrates in beetroot juice can be beneficial because they have been shown to increase the amount of nitric oxide in the blood and consequently widen blood vessels, support circulation, and support normal blood pressure.

Turmeric is a rhizomatous herbaceous perennial flowering plant of the ginger family, These compounds within turmeric are called curcuminoids, the most important of which is curcumin.

Curcumin is the main active ingredient in turmeric. The benefits turmeric confers are several all of which are anti-aging.
The most powerful benefits:

It’s a scientifically accepted fact that turmeric bolsters the body’s immune system. The massive benefits this miracle root offers, gives additional support to Cardio Miracle’s nitric oxide boosting ingredients while conferring potent anti-inflammatory properties.

Besides helping sustain normal metabolic function the B vitamins play an important role in regulating homocysteine levels in the blood. A New York study showed that homocysteine levels greater than 1200 microM “produced significant indirect suppression of eNOS activity.” The B vitamin group also helps regulate other chemicals that directly affect mitochondrial activity believed to eventually induce NO synthesis.

Vitamin B12 is an essential nutrient for the body, and is needed to protect DNA and RNA, support energy, protect nerve and brain cells, stimulate serotonin production, contribute to red blood cell formation, maintain skin, support digestion, and support immune function.

Why Vitamin B12 is so important for cardiovascular function?
One of the primary reactions of methylcobalamin in the body is to convert homocysteine to methionine - high homocysteine levels are undesirable and known to be an indicator of heart disease and stroke risk due to the fact free homocysteine in the blood causes atherosclerosis and venous thrombosis, putting strain on the vascular system and the heart. Vitamin B12 plays the part of regulating the levels of this hormone in the blood since it is produced whenever amino acids are broken down.

In addition, the conversion of homocysteine to methionine reduces the potential for damage because the methionine is the precursor to the super-antioxidant glutathione. Glutathione is the body's main antioxidant, protecting our cells from damage as well as the body’s master detoxifier.

There are some things that should be cleared up about vitamin B supplementation. Many companies opt to use the cheapest form which is produced in a lab. It’s called cyanocobalamin and it’s chemically synthesized, whereas the other form known as methylcobalamin is found in animal based foods and occurs naturally.

Why it’s important to know the difference between Methylcobalamin and Cyanocobalamin?
Cyanocobalamin contains a cyanide molecule. Although the amount of cyanide in a normal B12 supplement is small, your body still has to eliminate this compound. Methylcobalamin has a methyl group (just carbon and hydrogen) and it’s the methyl-compound that the human body needs to function properly.

Methylcobalamin is the superior vitamin B12 form.
Methylcobalamin is the most bio-available form of Vitamin B12, and it remains in the body for a longer period of time and at higher levels than cyanocobalamin. The body is supplied with vitamin B12 for longer with methylcobalamin than with cyanocobalamin. In addition, studies show methylcobalamin significantly improves visual accommodation, while cyanocobalamin is ineffective.

The most well studied use of methylcobalamin is focused on sleep, it appears that methylcobalamin is needed for the synthesis of melatonin. The research indicates that methylcobalamin can modulate melatonin secretion, enhance light-sensitivity, and normalize circadian rhythm.

Lastly, certain forms of vitamin B12 are essential for pain management and without it, the body would be unable to cope. The methyl form of vitamin B12 is needed to suppress the cytokine production and studies show it has the same pain reducing effect in patients that suffer from arthritis.

Vitamin B6, also known as pyridoxine, is a water-soluble vitamin your body needs for several functions. Your body cannot produce vitamin B6, so you must obtain it from foods or supplements. It’s significant to protein, fat and carbohydrate metabolism and the creation of red blood cells and neurotransmitters. Consuming adequate amounts of vitamin B6 is important for optimal health and may even prevent and treat chronic diseases.

Vitamin B6 rounds out Cardio Miracle providing foundational support to key body systems as well as ward off fatty build up in the arterial and cardiovascular system.

Vitamin D is an essential fat-soluble vitamin, sometimes called the sunshine vitamin.

It can either be obtained in the diet, through food and dietary supplements, or synthesized in the skin upon exposure to sunlight.

Although classified as a vitamin, it should be considered a prohormone because it is involved in many metabolic processes in the body.

Vitamin D plays a role in calcium and phosphorus balance important in bone health, and nerve and muscle activity. It also

In addition, Vitamin D is known to

• Fight disease
• Fight depression
• Boost weight loss
• regulate blood pressure
• boost immune function
• boost cell production
• regulate insulin secretion
• suppress parathyroid hormone and reduce bone degradation thus indirectly increasing bone mass.
• Vitamin D stimulates immune cells to break down the buildup of amyloid-β protein in the brain, playing a role in causing the Alzheimer’s disease

One serving of Cardio Miracle helps support normal vitamin D levels associated with optimal Nitric Oxide production and a therapeutic dose for disease prevention.

Vitamin K2 activates the calcium-binding actions of two proteins — matrix GLA protein and osteocalcin, which help to build and maintain bones.

Vitamin K2 optimizes calcium binding to the bone structure, and is an important nutrient to help reduce the potential for the development of osteoporosis. Vitamin K2 is an important ingredient that your body uses to direct calcium to stay in your bones and out of your heart and other body systems.

Why include Vitamin k2 in the form MK-7 rather than MK-4?
MK-7 is a form of vitamin K22 that has greater bioavailability than MK-4.

Research using the MK-7 form of vitamin K2 began about a decade ago. Likely due to its longer side chain conferring greater liposolubility, MK-7 has a much longer half-life than MK-4. This is a main reason that dosages of MK-7 may be as low as 45 µg daily and that single daily dosing is possible. The benefits of supplementing with K2 may be enhanced even further when combined with a vitamin D supplement, as these two vitamins have synergistic effects. Research indicates that the combination of Vitamin D and K provides synergistic support to the health of the blood vessels and skeletal system. We’ve added it to Cardio Miracle to provide foundational support of the body while delivering arterial cleansing through its nitric oxide boosting properties.

Calcium build-up in the arteries around your heart is a huge risk factor for heart disease. When calcification takes place in the blood vessels’ they can become stiff and fragile which can impede healthy blood flow to and from the heart. Therefore, anything that can reduce this calcium accumulation may help prevent heart disease.

Vitamin K2 is believed to help by preventing calcium from being deposited in your arteries. There is a highly plausible biological mechanism for its effectiveness and strong positive correlations with hear heatlh in observational studies. Long-term controlled trials on vitamin K2 and heart disease are needed.

Other Key Scientific Observations of Vitamin K2 Function.